You may disable comments under your Instagram post directly from your feed. This means that no (new) comments can be created under the corresponding post.
There are two ways to disable comments under an Instagram post. If there are already comments under the relevant post, select one of the comments. The context opens on the right. Here you can disable the comments via the three-dot menu.
If you want to restrict the comment function straight away, open your filter and select Instagram Media in the post types and select the respective profile. You also need to change the view from Unresolved to All items. Here you will find your own published posts and can also deactivate the comments via the three-dot menu.